In the globalized and competitive world of today, knowledge, innovation, and entrepreneurship are becoming more important, possibly even crucial for sustainable economic and social development. Since its EU 2020 strategy, the European Commission has been emphasizing the importance of education to prepare students for a changing world. Both the professional field and society are changing rapidly, necessitating skills to be successful in work and private life. There is more demand for critical thinking, creativity, and cooperation, which are needed to take on the challenges of the 21st century. These challenges require entrepreneurship, not only in the narrow sense of starting a business, but also more broadly in becoming more entrepreneurial and innovative. Educational institutes must therefore help students to become more creative, determined, and purposeful (i.e. to become more entrepreneurial (idem)). The present handbook hopes to give educators and entrepreneurs practical tools and insights to develop entrepreneurship education programmes that achieve this aim.